Animal testing is on its way out, study says

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Last summer, the National Institutes of Health announced that it’s phasing out experiments on chimpanzees. All but 50 of its 451 chimps will go to sanctuaries, and it won’t breed the remainder. The change is based on its 2011 study that determined that advancements have rendered human trials, computer-based research, and genetically modified mice more scientifically useful than chimps. The U.S. is late to this. Australia, Japan, and the E.U. have already banned or limited experiments on great apes in medical research. But the science community should take it further. We should work to end all animal testing for good.Ninety percent of drugs that pass animal testing then fail in human trials.It’s not just a moral question. Ethics aside, there are plenty of scientific reasons to push away from animal testing. The most important is that animal-based methods are being equaled or surpassed by other means. And the result is better science overall. Over the last 10 years, we’ve started replacing rodents with human cells in drug toxicity tests. But the biggest hurdle is probably testing efficacy: how well a drug treats a medical condition. A common tack is to genetically manipulate mice to imitate human diseases, but human and mouse genes still behave differently. In part because of this, 90 percent of drugs that pass animal testing then fail in human trials.Continue Reading…

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